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Symptoms of amyloidosis

Symptoms of amyloidosis

Amyloidosis is a rare disease, but there is usually fatal. It is due to the deposition of an abnormal protein called amyloid in tissues and organs of the body, which is most commonly produced by the bone marrow cells. Gradually protein leads to damage organ function, which accumulates. There are different types of amyloid, which are distinguished by the certain color characteristics.

The symptoms of amyloidosis are depending on the type of the affected organs. Therefore there is a great variety in terms of symptoms and signs that characterize the disease. This underlies the difficult diagnosis.

The most common symptoms of amyloidosis are:
– swelling of feet and ankles
– weakness
– weight loss
– asthma
– numbness in hands and feet
– diarrhea
– fatigue
– macroglossia (enlarged tongue)
– skin changes
– irregular heartbeat
– difficulty swallowing
In some cases they may be entirely absent symptoms.

The diagnosis of amyloidosis is relatively difficult. For this disease can be thought of in the discovery of elevated protein in urine and blood. A definite diagnosis, however, may be placed only after tissue biopsy. Usually the material is taken from various tissues and organs, the most common are fatty tissue in the abdomen, bone marrow, rectum. Then, the taken biopsy material were thoroughly examined under a microscope and with the aid of special coloring techniques for the presence of amyloid. It should be mentioned that there are different types of amyloid, suggesting the use of various techniques for precise detection of specific type of abnormal protein.


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